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In contrast to low ceruloplasmin levels observed in Wilson disease, the very rare genetic disorder of aceruloplasminemia presents with a more severe neurodegenerative phenotype including ataxia, unvoluntary movements, dystonia, tremor and chorea (34)

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The idea of tissue augmentation and volume replacement and our understanding of what can be achieved with these methods is increasing rapidly as more studies are being conducted

The stability of CO-binding to PGRMC1 was examined with UV-visible absorption spectra to chase temporal alterations for 2 h, as shown in Supplementary Fig